EFFICACY

MINJUVI^® PLUS LENALIDOMIDE: CAPTURES THE POTENTIAL FOR ANTI-TUMOUR RESPONSES IN R/R DLBCL TRANSPLANT INELIGIBLE PATIENTS, FROM 2L AND BEYOND¹

Objective response rate* (ORR) after at least 35 months’ follow-up** for full analysis set (FAS)¹

At 35 months, ORR was 57.5% (n=46/80), including a complete response (CR) in 40.0% (32/80) of patients¹

Adapted from Duell J, et al. 2021.¹

**Assessed by an Independent Review Committee; **data cut off October 2020;

†n=80 is the full analysis set from Duell J, et al. 2021¹. The MINJUVI SPC² refers to an intention-to-treat cohort of n=81 (ORR, 56.8%; CR, 39 .5%; PR, 17.3%).

ORR, objective response rate; CR, complete response; FAS, full analysis set; PR, partial response

AT ≥35 MONTHS*, MEDIAN DURATION OF RESPONSE (DOR) WAS 43.9 MONTHS¹

Secondary endpoint
Median DoR*: 43.9 months (n=80†; 95% CI: 26.1–NR)

At 36 months, an estimated 80.1% (n=64/80) of patients with a CR continued to respond¹

Adapted from Duell J, et al. 2021.¹

*Assessed by an Independent Review Committee. †n=80 is the full analysis set from Duell J, et al. 2021¹. The MINJUVI SmPC² refers to an intention-to-treat cohort of n=81 (DoR, 43.9 months (95% CI: 26.1–NR)).

TREATMENT WITH MINJUVI^® PLUS LENALIDOMIDE PROVIDED SURVIVAL BENEFITS FOR TRANSPLANT INELIGIBLE PATIENTS WITH R/R DLBCL¹

Data from Duell J, et al. 2021.¹

n=80 is the full analysis set from Duell J, et al. 2021. The MINJUVI SmPC refers to an intention-to-treat cohort of n=81 (DoR, 43.9 months (95% CI: 26.1–NR)¹

An estimated 81.3% of patients with a CR were alive at 36 months¹

L-MIND evaluated the safety and efficacy of MINJUVI^® plus lenalidomide in adult patients with transplant ineligible NTE R/R DLBCL who were not candidates for high-dose chemotherapy and autologous stem cell transplant (ASCT),and who had received 1–3 prior systemic regimens (including at least one anti-CD20-containingtherapy).^1,4

Primary endpoint:

ORR, defined as the proportion of complete and partial responders, assessed according to the 2007 International Working Group response criteria for malignant lymphoma⁴

Secondary endpoints:¹

DoR, defined as time from initial CR or partial response (PR) to first observation of progressive disease (PD) as assessed by an independent review committee using the International Working Group response criteria⁴
Progression-free survival (PFS), defined as the time from first dosing to lymphoma progression or death as assessed by an independent review committee
OS, defined as the time from first dosing to date of death
Adverse event (AE), incidence and severity¹

Dosing schedule

MINJUVI^® was administered over 28-day cycles (12 mg/kg intravenously), once weekly during Cycles 1–3, with a loading dose on Day 4 of Cycle 1, then every 2 weeks during Cycles 4–12. Lenalidomide (25 mg orally) was administered on Days 1–21 of Cycles 1–12
Following Cycle 12, progression-free patients received MINJUVI^® twice weekly until disease progression or unacceptable toxicity²

Select baseline characteristics from L-MIND (N=81)¹

	ALL PATIENTS (N=81)
Median age (range)	72 years (41–86 years)
Age >70 years	45 (56%)
Stage III/IV	61 (75%)
ILD	45 (56%)
IPI 3–5	41 (51%)
Median prior treatment lines (range)	2 (1–4)
Cell of origin (by immunohistochemistry) GCB Non-GCB Unknown	39 (48%) 22 (27%) 20 (25%)
Cell of origin (gene expression profiling) GCB Activated B-cell Unclassified Not evaluable Missing	8 (10%) 20 (25%) 6 (7%) 5 (6%) 42 (52%)
Patients with transformed lymphoma B-cell lymphoma Marginal zone lymphoma NHL unspecified histology Case reported by central pathology review	4 (5%) 2 (3%) 1 (1%) 1 (1%)

Data from Duell J, et al. 2021.¹ Additional study details, including full inclusion/exclusion criteria, can be found on the L-MIND trial webpage.⁵

AE, adverse event; ASCT, autologous stem cell transplant; CI, confidence interval; CR, complete response; DLBCL, diffuse large B-cell lymphoma; DoR, duration of response; FAS, full analysis set; GCB, germinal-centre B-cell; ILD, increased lactase dehydrogenase; IPI, International Prognostic Index; NE, not evaluable; NHL, non-Hodgkin lymphoma; NR, not reached; NTE, non-transplant eligible; ORR, objective response rate; OS, overall survival; PD, progressive disease; PFS, progression-free survival; PR, partial response; R/R, relapsed/refractory; SD, stable disease; SmPC, Summary of Product Characteristics.

CAPTURE THE POTENTIAL FOR ANTI-TUMOUR RESPONSES FOR YOUR TRANSPLANT INELIGIBLE PATIENTS WITH R/R DLBCL

MINJUVI^® BENEFITS AT SECOND LINE

View post-hoc analysis data showing benefits of MINJUVI^® plus lenalidomide at second- versus later-line use

SAFETY PROFILE

Learn about the safety profile of MINJUVI^® plus lenalidomide

MINJUVI^® SmPC

Local product information

UK Prescribing Information

ROI Prescribing Information

References:

Duell J, et al. Haematologica 2021; 106.
MINJUVI (tafasitamab) SPC. May 2022. https://www.medicines.org.uk/emc/product/13003/smpc. Last accessed, January 2025.
MINJUVI (tafasitamab) EU SmPC. https://www.ema.europa.eu/en/documents/product-information/minjuvi-epar-product-information_en.pdf. Last accessed, January 2024.
Salles G, et al. Lancet Oncol 2020; 21(7): 978–88.
ClinicalTrials.gov. Available at: https://clinicaltrials.gov/ct2/show/NCT02399085; Last accessed, January 2024.
Duell J, et al. J Clin Oncol 2021; 39(Suppl 15): 7513.
Duell J, et al. Hematol Oncol 2021; 39 (Suppl S2): 58–61.
Salles G, et al. Lancet Oncol 2020; 21 (supplementary appendix).

This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions.

Adverse events in the UK should be reported.

Reporting forms and information can be found at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.

Adverse events should also be reported to Incyte by calling 00‑800‑0002‑7423

Adverse events in ROI should be reported.

Reporting forms and information can be found at HPRA Pharmacovigilance: www.hpra.ie

Adverse events should also be reported to Incyte immediately by phoning the Toll-free phone number 1800456748

CI, confidence interval; CR, complete response; DLBCL, diffuse large B-cell lymphoma; DoR, duration of response; ORR, objective response rate; OS, overall survival; PFS, progression-free survival; PR, partial response; R/R, relapsed/refractory; SmPC, Summary of Product Characteristics; 2L, second line.

MINJUVI^® UK prescribing information MINJUVI^® ROI prescribing information MINJUVI^®SmPC Privacy Policy Cookie Policy Terms of Use

Marketing authorisation holder:

United Kingdom:

Incyte Biosciences UK Ltd,

First Floor Q1, The Square,

Randalls Way, Leatherhead,

KT22 7TW, UK

The MINJUVI logo and the Incyte logo are registered trademarks of Incyte.

IE/MJVI/P/25/0005

Date of preparation: September 2025

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EFFICACY

MINJUVI® PLUS LENALIDOMIDE: CAPTURES THE POTENTIAL FOR ANTI-TUMOUR RESPONSES IN R/R DLBCL TRANSPLANT INELIGIBLE PATIENTS, FROM 2L AND BEYOND1

At 35 months, ORR was 57.5% (n=46/80), including a complete response (CR) in 40.0% (32/80) of patients1

AT ≥35 MONTHS*, MEDIAN DURATION OF RESPONSE (DOR) WAS 43.9 MONTHS1

Secondary endpointMedian DoR*: 43.9 months (n=80†; 95% CI: 26.1–NR)

At 36 months, an estimated 80.1% (n=64/80) of patients with a CR continued to respond1

TREATMENT WITH MINJUVI® PLUS LENALIDOMIDE PROVIDED SURVIVAL BENEFITS FOR TRANSPLANT INELIGIBLE PATIENTS WITH R/R DLBCL1

An estimated 81.3% of patients with a CR were alive at 36 months1

L-MIND: AN OPEN-LABEL, MULTICENTRE, SINGLE-ARM, PHASE-II STUDY